Name: LeuSynergy™
Brand: nuHx
SKU: 300122624
Price: 79.00 USD
Availability: InStock

New Formulation, New Price, New Opportunities!

$79.00

An exercise and caloric restriction mimetic that works on NAD+ efficiency and sirt1 activation. This low-dose leucine compound is best known for its incredible enhancement of weight loss with GLP 1’s like semaglutide.
LeuSynergy + GLP-1s has become a foundational protocol for weight loss and metabolism optimization.

Per Bottle

120 capsules

Serving Size

Directions

2 capsules in the morning and 2 capsules 90 minutes after lunch.

Amount per serving
L-Leucine	1100mg t
Vitamin B6 (as Pyridoxal 5 Phosphate)	15mg t
Resveratrol (from Polygonum Cuspidatum Extract) (NLT 98% Resveratrol)	50mg t
† Daily Value (DV) not established

Cellular Pathways

Delivering the right dose of Leucine decreases the amount of NAD needed to activate SIRT-1

Leucine at a concentration of 0.5mM was shown to decrease the kM of NAD by 50%.

With Leucine, LESS NAD+ is needed for SIRT-1 functions, improving NAD+ utilization in other cellular pathways.

Why this matters:

SIRT-1 Downstream Effects

Stimulates caloric restriction and exercise pathways through these gene transcription factors:

Clinical Studies

Leucine-Resveratrol Synergy

Human Pre-diabetic Subjects Randomized:

Leucine 1.1 g + Resveratrol 50mg Twice Daily vs. Placebo

OGTT and 60 min glucose and insulin concentration
Reduced insulin resistance by 33%
Significant improvement and insulin/glucose dynamics

* Lipps J, Hagan S, Clark M, Davis D, Stone L, Survant L, et al.: Resveratrol synergy in pre-diabetes. Diabetes 2013;62: Poster 78-LB

Weight Loss – Fat Oxidation – Insulin Sensitivity

Synergy with GLP-1s

Semaglutide, Tirzepatide, LiraglutideStudies show 15% reduction in body weight when semaglutide was accompanied by caloric restriction and exercise. Using an exercise mimetic like LeuSynergy is foundational in weight loss and metabolic health outcomes.

GLP-1
Increase in GLUT4 expression by activating AMPK

SIRT-1
Increase in GLUT4 expression through SIRT1 deacetylation of PGC-1a

GLP-1
Direct effects on hepatocytes by activating genes involved in beta-oxidation of fatty acids

SIRT-1
Activation of PGC-1a and PPAR resulting in an increase in fatty acid oxidation and oxidative phosphorylationn

GLP-1
Reduced oxidative stress in pancreatic islets. Increases B-cell mass by regulating cell kinetics and suppressing oxidative and ER stress, and amerlioration of glucolipotoxicity.

SIRT-1
SIRT-1 deacetylation and inhibition of NF-kB protecting beta cells from oxidative stress and inflammatory cytokines.